Water transport becomes uncoupled from K+ siphoning in brain contusion, bacterial meningitis, and brain tumours: immunohistochemical case review

Water transport becomes uncoupled from K+ siphoning in brain contusion, bacterial meningitis, and brain tumours: immunohistochemical case review.

Specimens of normal human brain, contused brain, brain with bacterial meningitis, and brain tumours were immunolabelled for aquaporin 4 (AQP4) and Kir4.1. In normal brain tissue, AQP4 and Kir4.1 were detected around the microvessels. In pathological brain tissue, AQP4 was upregulated in astrocytes in oedematous regions and Kir4.1 was upregulated in astrocytes in damaged brain. Changes in alpha ...

Nitric Oxide in Brain Contusion

Trauma to the brain is a leading cause of death and disability. The primary injury initiates a cascade of biochemical reactions in the brain that causes further neuronal damage, a process referred to as secondary brain injury. The mechanisms for secondary brain injury are not fully understood and successful treatments for traumatic brain injury (TBI) still remain elusive. This study was underta...

Brain MRI Findings of Complicated Meningitis in Children: A Cross Sectional Study from Central Iraq

Background Meningitis is a common neurological emergency and a leading cause of death and neurological disability worldwide. MRI is extremely useful for detecting and monitoring the complications of meningitis. The purpose of this study was to describe the brain MRI findings in children with complicated meningitis. Materials and Methods  This cross-sectional study was conducted in Radiology De...

Na-K Transport in Canine Brain

This study examines the relation between Na-K transport and metabolism in the canine brain. Cerebral oxygen and glucose consumption was measured by the sagittal sinus outflow technique. Synaptic transmission and related metabolism was blocked by pentobarbital 40 mg/kg (EEG flat). Lidocaine blocked an additional 15-20%, presumably by restricting Na-K leak fluxes and reducing the demand for Na-K ...

The Blood-Brain Barrier in Brain Tumours